1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

PurposeAlthough an increasing body of literature suggests a relationship between brain irradiation and deterioration of neurocognitive function, it remains as the standard therapeutic and prophylactic modality in patients with brain tumors. This review was aimed to abstract and evaluate the prediction models for radiation-induced neurocognitive decline in patients with primary or secondary brain tumors.MethodsMEDLINE was searched on October 31, 2021 for publications containing relevant truncation and MeSH terms related to “radiotherapy,” “brain,” “prediction model,” and “neurocognitive impairments.” Risk of bias was (...) assessed using the Prediction model Risk Of Bias ASsessment Tool.ResultsOf 3,580 studies reviewed, 23 prediction models were identified. Age, tumor location, education level, baseline neurocognitive score, and radiation dose to the hippocampus were the most common predictors in the models. The Hopkins verbal learning and the trail making tests were the most frequent outcome assessment tools. All studies used regression as machine learning method. All models were judged to have a high risk of bias mainly due to issues in the analysis.ConclusionExisting models have limited quality and are at high risk of bias. Following recommendations are outlined in this review to improve future models: developing cognitive assessment instruments taking into account the peculiar traits of the different brain tumors and radiation modalities; adherence to model development and validation guidelines; careful choice of candidate predictors according to the literature and domain expert consensus; and considering radiation dose to brain substructures as they can provide important information on specific neurocognitive impairments. (shrink)

CONTENTS An Editor's Introduction INTRODUCTORY CHRONOLOGICAL OVERVIEW HEIDEGGER'S ACADEMIC CAREER 1909-1930 A. Background B. Lehrveranstaltungen/University Education and Teaching C. Heidegger's Early Occasional Writings: A Chronological Bibliography PART I: STUDENT YEARS 1. Curricula Vitae 2. Two Essays for The Academician o Authority and Freedom o On a Philosophical Orientation for Academics 3. The Problem of Reality in Modern Philosophy 4. Recent Research in Logic 5. Meßkirch's Triduum: A Three-day Meditation on the War 6. Question and Judgment 7. The Concept of Time (...) in the Science of History 8. The Doctrine of Categories and Meaning in Duns Scotus : Supplements o Author's Notice o Conclusion: The Problem of Categories 9. On Schleiermacher's Second Speech "On the Essence of Religion" PART II: EARLY FREIBURG PERIOD 10. Letter to Engelbert Krebs on his Philosophical Conversion 11. Letter to Karl L÷with on his Philosophical Identity 12. Vita, with an Accompanying Letter to Georg Misch 13. Critical Comments on Karl Jaspers' Psychology of Worldviews 14. Phenomenological Interpretations with Respect to Aristotle: Indication of the Hermeneutical Situation PART III: THE MARBURG PERIOD 15. The Problem of Sin in Luther 16. The Concept of Time 17. Being-There and Being-True According to Aristotle 18. Wilhelm Dilthey's Research and the Current Struggle for a Historical Worldview 19. On the Essence of Truth, Pentecost Monday 20. Letter Exchange with Karl L÷with on Being and Time 21. "Phenomenology," Draft B, with Heidegger's Letter to Husserl 22. "Heidegger, Martin": Lexicon Article Attributed to Rudolf Bultmann APPENDICES: SUPPLEMENTS BY HEIDEGGER'S CONTEMPORARIES Appendix I: Academic Evaluations of Heidegger by his Teachers and Peers A. Evaluation of Martin Heidegger's Dissertation by Arthur Schneider B. Evaluation of Dr. Heidegger's Habilitation by Heinrich Rickert C. Nomination for Associate Professor at G÷ttingen D. Nomination for Associate Professor at Marburg E. Nomination for Professor at Marburg F. Nomination for Husserl's Chair at Freiburg Appendix II: Husserl and Heidegger A. Their Correspondence to and about Each Other B. "For Edmund Husserl on his Seventieth Birthday" Appendix III: Karl L÷with's Impressions of Husserl and Heidegger, 1926-1927 Annotated Glossary Bibliography of GA-Editions of the Lecture Courses Select Secondary Bibliography. (shrink)

CONTENTS An Editor's Introduction INTRODUCTORY CHRONOLOGICAL OVERVIEW HEIDEGGER'S ACADEMIC CAREER 1909-1930 A. Background (1889-1930) B. Lehrveranstaltungen/University Education and Teaching (1909-1930) C. Heidegger's Early Occasional Writings: A Chronological Bibliography PART I: STUDENT YEARS 1. Curricula Vitae 2. Two Essays for The Academician o Authority and Freedom (1910) o On a Philosophical Orientation for Academics (1911) 3. The Problem of Reality in Modern Philosophy (1912) 4. Recent Research in Logic (October-December 1912) 5. Meßkirch's Triduum: A Three-day Meditation on the War (January 1915) (...) 6. Question and Judgment (July 1915) 7. The Concept of Time in the Science of History (July 1915) 8. The Doctrine of Categories and Meaning in Duns Scotus (1915): Supplements o Author's Notice (1917) o Conclusion: The Problem of Categories (1916) 9. On Schleiermacher's Second Speech "On the Essence of Religion" (1917) PART II: EARLY FREIBURG PERIOD 10. Letter to Engelbert Krebs on his Philosophical Conversion (1919) 11. Letter to Karl L÷with on his Philosophical Identity (1921) 12. Vita, with an Accompanying Letter to Georg Misch (June 1922) 13. Critical Comments on Karl Jaspers' Psychology of Worldviews (1920) 14. Phenomenological Interpretations with Respect to Aristotle: Indication of the Hermeneutical Situation (1922) PART III: THE MARBURG PERIOD 15. The Problem of Sin in Luther (February 1924) 16. The Concept of Time (July 1924) 17. Being-There and Being-True According to Aristotle (December 1924) 18. Wilhelm Dilthey's Research and the Current Struggle for a Historical Worldview (Kassel Lectures, April 1925) 19. On the Essence of Truth, Pentecost Monday (May 24, 1926) 20. Letter Exchange with Karl L÷with on Being and Time (August 1927) 21. "Phenomenology," Draft B (of the Encyclopaedia Britannica Article), with Heidegger's Letter to Husserl (October 1927) 22. "Heidegger, Martin": Lexicon Article Attributed to Rudolf Bultmann (1927-1928) APPENDICES: SUPPLEMENTS BY HEIDEGGER'S CONTEMPORARIES Appendix I: Academic Evaluations of Heidegger by his Teachers and Peers A. Evaluation of Martin Heidegger's Dissertation by Arthur Schneider (July 1913) B. Evaluation of Dr. Heidegger's Habilitation by Heinrich Rickert (July 1915) C. Nomination for Associate Professor at G÷ttingen (November 1922) D. Nomination for Associate Professor at Marburg (December 1922) E. Nomination for Professor at Marburg (August 1925) F. Nomination for Husserl's Chair at Freiburg (February 1928) Appendix II: Husserl and Heidegger A. Their Correspondence to and about Each Other (1914-1934) B. "For Edmund Husserl on his Seventieth Birthday" (April 8, 1929) Appendix III: Karl L÷with's Impressions of Husserl and Heidegger, 1926-1927 Annotated Glossary Bibliography of GA-Editions of the Lecture Courses Select Secondary Bibliography. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Direct Nuclear Reprogramming: Response to Condic, Lee, and GeorgeGerard Magill, Ph.D. and William B. NeavesWe read with great interest the response of Maureen Condic, Patrick Lee, and Robert George (2009) to our essay, “Ontological and Ethical Implications of Direct Nuclear Reprogramming” in the March 2009 issue of the Kennedy Institute of Ethics Journal (Magill and Neaves 2009). Much of their response addressed issues that are not in dispute: somatic (...) cells are not zygotes, neurons and hepatocytes are different, growth-factor signals from the trophoblast influence development of the inner cell mass, membranes derived from the trophectoderm are critically required for embryonic survival, and stem cells cannot produce a fetus “on their own.”The crucial point of disagreement deals with the fact that iPS cells are not totipotent but zygotes are. Zygotes can generate their own placental structures while iPS cells must be given them through tetraploid complementation. Condic, Lee, and George consider totipotency to be crucial to natural potentiality. We present an alternative view in our essay (Magill and Neaves 2009, pp. 28–29). Placental structures make no lasting contribution to the postnatal organism, and the equivalency of iPS cells with the inner cell mass of the blastocyst is apparent from tetraploid complementation experiments.The respondents acknowledge the following:... somatic cells can be “converted” into zygotes by the process of somatic cell nuclear transfer (SCNT) or direct reprogramming in combination with tetraploid complementation—just as sperm and egg cells can be “converted” into a zygote by the process of natural fertilization—....(Condic, Lee, and George 2009, p. 35)As the respondents recognize, different ways of manipulating cells can lead to embryogenesis: sperm and egg cells in the process of natural fertilization, the enucleated egg and an ordinary body cell in the process of somatic cell nuclear transfer, and reprogrammed skin cells and a tetraploid blastocyst in the case of induced pluripotent stem (iPS) cells. In each case, different cells are manipulated—or “converted” in the respondents’ terminology—in a process that alters their biological fate within a supportive environment facilitating embryogenesis.The developmental potential that resides in the human genome does not unfold in isolation, not even in a zygote. In all cases, whether involving a zygote or an iPS cell, interaction with a supportive environment is required to express the developmental program residing in the genome. [End Page 201]This biological reality supports what we have described as “early cellular development along the continuum of natural potentiality that can result in the formation of a fetus” (Magill and Neaves 2009, p. 30), and it presents a significant challenge to the natural potentiality argument.Gerard MagillVernon F. Gallagher Chair for the Integration of Science, Theology, Philosophy, and Law, and Professor, Center for Healthcare Ethics Duquesne University Pittsburgh, PA.William B. NeavesPresident and CEO Stowers Institute for Medical Research and Professor of Basic Medical Science University of Missouri at Kansas City School of Medicine Kansas City, MOReferencesCondic, Maureen L.; Lee, Patrick; and George, Robert P. 2008. Ontological and Ethical Implications of Direct Nuclear Reprogramming: Response to Magill and Neaves. Kennedy Institute of Ethics Journal 19: 33–40. Google ScholarMagill, Gerard, and Neaves William B. 2009. Ontological and Ethical Implications of Direct Nuclear Reprogramming. Kennedy Institute of Ethics Journal 19: 23–32. Google ScholarCopyright © 2009 The Johns Hopkins University Press... (shrink)

In his article ‘God and Probability’, 1 Hugh Mellor introduced the notion of the ‘bridge-hand fallacy’, allegedly committed by those who think they can appeal to probabilities in arguments for design. I should like to give this notion another airing, partly because of its recent criticism in two interesting books - R. G. Swinburne' The Existence of God and D. J. Bartholomew's God of Chance - and partly because it seems worth asking how it fares in relation to the most (...) recent examples of design argument, namely those which appeal to the so-called ‘anthropic principle’ in cosmology. (shrink)

Does the recent success of Podemos and Syriza herald a new era of inclusive, egalitarian left populism? Because leaders of both parties are former students of Ernesto Laclau and cite his account of populism as guiding their political practice, this essay considers whether his theory supports hope for a new kind of populism. For Laclau, the essence of populism is an “empty signifier” that provides a means by which anyone can identify with the people as a whole. However, the concept (...) of the empty signifier is not as neutral as he assumes. As I show by analyzing the role of race in his theory, some subjects are constituted in a way that prevents their unmediated identification with the people. Consequently, Laclau’s view should be read as symptomatic of the problems with populist logic if its adherents are to avoid reproducing its exclusions and practice a more inclusive politics. (shrink)

A comparative study of Zumel's and other scholastic theories concerning the influence of the understanding or reason upon the will.--L. K. B.

B L Curtis; Learning and Intentionality, Journal of Philosophy of Education, Volume 5, Issue 1, 30 May 2006, Pages 105–121, https://doi.org/10.1111/j.1467-9752.

B L Curtis; Learning and Intentionality, Journal of Philosophy of Education, Volume 5, Issue 1, 30 May 2006, Pages 105–121, https://doi.org/10.1111/j.1467-9752.

There is now a rapidly expanding population of interlinked developmental biology databases on the World Wide Web that can be readily accessed from a desk‐top PC using programs such as Netscape or Mosaic. These databases cover popular organisms (Arabidopsis, Caenorhabditis, Drosophila, zebrafish, mouse, etc.) and include gene and protein sequences, lists of mutants, information on resources and techniques, and teaching aids. More complex are databases relating domains of gene expression to embryonic anatomy and these range from existing text‐based systems for (...) specific organs such as kidney, to a massive project under development, that will cover gene expression during the whole of mouse embryogenesis. In this brief article, we review selected examples of databases currently available, look forward to what will be available soon, and explain how to gain access to the World Wide Web. (shrink)

On August 29, 1995, the United States District Court for the Northern District of Ohio ruled that certain practices of Blue Cross and Blue Shield of Ohio relating to the calculation of copayments on insurance claims violated provisions of ERISA, and thus BCBSO could be liable for unpaid benefits and breach of fiduciary duty ). According to BCBSO's Explanation of Benefits and Schedule of Benefits, beneficiaries were responsible for a 20 percent copayment for hospital charges, and the remaining 80 percent (...) of the Provider's Reasonable Charges would be paid by BCBSO. BCBSO negotiated with the hospitals to create discount agreements whereby the actual charge to BCBSO was less than 80 percent of the total amount of the hospital's charges. By this arrangement, BCBSO paid less than 80 percent of what patients were billed; concurrently, patients paid more than 20 percent of the amount ultimately paid to hospitals for their services. (shrink)